hrp0084fc9.1 | Beta cell disorders | ESPE2015

Islet δ-Cells Contribute to the Pathobiology of Atypical Congenital Hyperinsulinism

Han Bing , Bourke Siobahn , Mohammad Zainab , Craigie Ross , Skae Mars , Cheeseman Edmund , Banerjee Indi , Cosgrove Karen , Dunne Mark

Background: Atypical forms of congenital hyperinsulinism in infancy (CHI-A) represent a novel subgroup of patients who present later in the neonatal period; have poor responses to medical intervention; an unremarkable histopathology and no known genetic cause of disease.Objective and hypotheses: To compare the expression profiles of insulin and somatostatin in islets from patients with CHI-A, diffuse CHI (CHI-D) and age-matched control tissue.<p clas...